The Role of Early Intravenous Immunoglobulin and Nursing Process Optimization in Modulating Inflammation and Improving Outcomes in Pediatric Severe Adenovirus Pneumonia: A Comprehensive Review
https://doi.org/10.22034/thr.2025.236668
Salayeva Navbahor, Docent. Sevara Sadullayeva, Ollaberganov Zayniddin Umarbekovich, Niginabonu Khajiqurbonova, Sultanov Muhammad, Saginova Aygerim Sisenbayevna
Abstract Background: Severe adenovirus pneumonia (SAP) in children is a critical illness characterized by a dysregulated hyperinflammatory response. The adjunctive role of early intravenous immunoglobulin (IVIG) and optimized nursing care in modulating this inflammation remains a key area of clinical investigation.
Objective: This review evaluated current evidence on the efficacy of early IVIG administration and nursing process optimization (NPO) in improving clinical and biochemical outcomes for pediatric SAP.
Methods: A comprehensive analysis of clinical studies, including a pivotal randomized controlled trial was conducted. The review focuses on IVIG's immunomodulatory mechanisms and the impact of structured nursing interventions on care delivery.
Results: Early IVIG administration is associated with significant reductions in key inflammatory markers (CRP, PCT, IL-8) and leads to superior clinical outcomes, including shorter hospital stays, fever duration, and mechanical ventilation requirements, alongside lower complication rates. Concurrently, implementing NPO protocols dramatically reduces infusion-related adverse events.
Conclusion: The synergistic application of early IVIG and NPO presents a promising, holistic strategy for managing pediatric SAP by effectively modulating inflammation and enhancing the safety of care delivery. This combined approach warrants broader clinical adoption and further long-term study
The Influence of Low Molecular Weight Heparin and Early Enteral Nutrition on Immune, Coagulation, Inflammatory, and Nutritional Indicators in Hyperlipidemic Acute Pancreatitis: An In-Depth Analysis
https://doi.org/10.22034/thr.2025.236658
Mohammed Ibrahim Mohialdeen Gubari
Abstract Backgrounds: Hyperlipidemic acute pancreatitis (HLAP) is a growing and serious subtype of acute pancreatitis, involving a complicated interaction of metabolic imbalance, widespread inflammation, and clotting irregularities. The potential of low molecular weight heparin (LMWH) and early enteral nutrition (EEN) as supplementary treatments has attracted considerable attention for their ability to influence central disease mechanisms.
Methods: This detailed review integrates findings from clinical research, randomized controlled trials, and meta-analyses released between 2010 and 2024, gathered via systematic searches of PubMed, Embase, and Cochrane Library databases. Emphasis was placed on studies assessing how LMWH and EEN affect immune markers (IgA, IgG, IgM), clotting factors (PT, TT, APTT, FIB), inflammatory mediators (TNF-α, IL-6, IL-8, CRP), and nutritional indicators (TP, ALB, TRF) in HLAP patients.
Results: Current data suggest that using LMWH together with EEN produces better patient results than traditional care alone. Notable outcomes involve a marked decrease in inflammatory markers, better clotting function, higher antibody levels, and improved nutritional measures. This combined method is linked to reduced hospitalization time, quicker return of digestive function, and fewer complications like multiple organ failure.
Conclusion: The complementary actions of LMWH and EEN tackle the diverse causes of HLAP. LMWH enhances blood flow in the pancreas while lowering excessive clotting and inflammation, whereas EEN protects intestinal lining and helps regulate immunity. Subsequent studies should aim to establish consistent treatment guidelines and determine which patients would gain the most from this dual therapy.