Mazandaran Association of Emergency Medicine Translational Health Reports 3092-6750 1 1 2025 11 17 Effect of Inhaled Salbutamol on Pain Severity in Patients Presenting with Acute Renal Colic: A Double-Blind Randomized Clinical Trial 234477 10.22034/thr.2025.531758.1016 EN Seyed Mohammad Hosseininejad Assistant Professor of Emergency Medicine, Mazandaran University of Medical Sciences, Sari, Iran Iraj Goli Khatir Assistant Professor of Emergency Medicine, Mazandaran University of Medical Sciences, Sari, Iran Hoseinali Khodadadi Department of Emergency Medicine, Mazandaran University of Medical Sciences, Sari, Iran Journal Article 2025 06 29 Background: Renal colic is a common and severely painful emergency condition often caused by ureteral stones. Rapid pain management is critical. This study evaluates the efficacy of inhaled salbutamol, a β2-agonist with smooth muscle relaxant properties, as an adjunct therapy in reducing pain severity in patients with acute renal colic.<br /><br /> Methods: In this double-blind randomized controlled trial, 204 patients with moderate renal colic pain (based on the Visual Analog Scale, VAS) referred to the emergency department of Imam Khomeini Hospital in Sari, Iran, were randomly assigned to two groups. The intervention group received 30 mg intravenous ketorolac and inhaled salbutamol (5 puffs), while the control group received ketorolac and a placebo inhalation. Pain intensity, vital signs, and symptoms such as nausea and vomiting were recorded at baseline and at intervals of 10, 20, 30, 45, 60, and 120 minutes after treatment.<br /><br /> Results: Pain intensity significantly decreased over time in both groups (p https://www.threports.com/article_234477_18a6df65c925ed786618e6b5c1fa7551.pdf