Mazandaran Association of Emergency Medicine Translational Health Reports 3092-6750 2 1 2025 12 20 The Influence of Stereotactic Body Radiotherapy (SBRT) on Biomarker Profiles in Lung Cancer: A Detailed Overview 236663 10.22034/thr.2025.236663 EN Babak Olia Department of Radiology, Faculty of Veterinary Medicine, Science and Research Branch, Tehran, Iran Karomat Sobirova Department of Pedagogy and Psychology, Urgench State University, Urgench, Uzbekistan Masharipova Ravqat Department of Medicine, Mamun University, Khiva, Uzbekistan Madrimov Javoxir Islombek O'g'li Department of Medicine, Urgench Mamun University, Urgench, Uzbekistan Niginabonu Khajiqurbonova Department of Clinical Subjects, Tashkent State Medical University, Tashkent, Uzbekistan Fayzullayev Umidjon O'ktamovich Department of Psychology, Mamun University, Khiva, Uzbekistan Ulliyeva Rayxon Department of Psychology, Mamun University, Khiva, Uzbekistan Ataniyazov Aybek Department of General Science, Tashkent State University of Economics, Uzbekistan Mahdi Hazratgholi Department of Radiology, Imam Khomeini Hospital Complex, School of Medicine, Tehran University of Medical Sciences (TUMS), Tehran, Iran 0009-0004-0851-3588 Journal Article Background: Stereotactic Body Radiation Therapy (SBRT) represents the standard treatment for inoperable early-stage non-small cell lung cancer (NSCLC) and is increasingly utilized for oligometastatic disease. Its distinct radiobiological profile, involving high doses per fraction, triggers complex tumor-killing effects and systemic biological reactions not fully detectable through conventional imaging. Objective: This review aims to summarize and critically assess current evidence regarding dynamic alterations in circulating, tissue, and imaging biomarkers after SBRT for lung cancer, and to explore their clinical significance. Methods: A narrative synthesis of scientific literature from PubMed, Scopus, and Google Scholar was conducted, focusing on studies published between 2005 and 2024. Key search terms included "SBRT," "SABR," "lung cancer," "biomarker," "ctDNA," "immunotherapy," "cytokines," and "radiation pneumonitis." Results: SBRT prompts a rapid, biphasic shift in tumor-derived biomarkers such as circulating tumor DNA (ctDNA), characterized by an initial post-treatment surge followed by reduction in responders. It significantly influences the immune system, inducing immunogenic cell death, expanding tumor-specific T-cell populations, and increasing checkpoint molecule expression like PD-L1. Additionally, SBRT modifies levels of cytokines (e.g., IL-6, TGF-β) and angiogenic factors (e.g., VEGF), which correlate with both treatment effectiveness and side effects like radiation-induced lung injury. Certain genetic polymorphisms also appear promising for predicting toxicity risk. Conclusion: SBRT induces a dynamic and multifaceted change in the biomarker profile of lung cancer patients. These biomarkers offer considerable potential for personalizing treatment, predicting outcomes, monitoring response, and rationally planning combination therapies, especially with immunotherapy. Future prospective and validated studies are necessary to integrate these findings into clinical practice.

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