Mazandaran Association of Emergency Medicine Translational Health Reports 3092-6750 2 1 2025 12 20 Current Insights into Pathophysiology, Clinical Presentation, and Minimally Invasive Management of Renal Peripelvic Cysts, A Narrative Review 236665 10.22034/thr.2025.563719.1031 EN Shahabaldin Bagheri Department of General Surgery, School of Medicine, Mazandaran University of Medical Sciences, Sari, Mazandaran, Iran Behkam Rezaiemehr Department of Urology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Mazandaran, Iran Mojtaba Yousefi Zoshk Trauma Research Center, Aja University of Medical Sciences, Tehran, Iran Assistant professor of Pediatrics Department, Aja University of Medical Sciences Masoud Maboudi Assistant Professor, Antimicrobial Resistance Research Center, Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran Amirsaleh Abdollahi Student Research Center, School of Medicine, Mazandaran University of Medical Sciences, Sari, Mazandaran, Iran Mehdi Younesi Rostami Department of Urology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Mazandaran, Iran Mohammad Javad Bay Student Research Center, School of Medicine, Mazandaran University of Medical Sciences, Sari, Mazandaran, Iran Ahmad Deylami Department of Urology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Mazandaran, Iran Journal Article 2025 12 02 <strong><span style="font-size: 12.0pt; line-height: 150%; font-family: 'Times New Roman',serif; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-theme-font: major-bidi; mso-bidi-language: FA;">Background:</span></strong><span style="font-size: 12.0pt; line-height: 150%; font-family: 'Times New Roman',serif; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-theme-font: major-bidi; mso-bidi-language: FA;"> Renal peripelvic (parapelvic) cysts cause hydronephrosis, pain, and obstruction when exceeding 4-5 cm due to hilar compression, with elevated IL-6, TNF-α, and creatinine reflecting inflammation and impaired function.​</span><br><strong><span style="font-size: 12.0pt; line-height: 150%; font-family: 'Times New Roman',serif; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-theme-font: major-bidi; mso-bidi-language: FA;">Objective:</span></strong><span style="font-size: 12.0pt; line-height: 150%; font-family: 'Times New Roman',serif; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-theme-font: major-bidi; mso-bidi-language: FA;"> This narrative review synthesizes evidence on pathophysiology, diagnosis, and minimally invasive management, emphasizing retroperitoneoscopic decortication versus ureteroscopic drainage outcomes.​</span><br><strong><span style="font-size: 12.0pt; line-height: 150%; font-family: 'Times New Roman',serif; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-theme-font: major-bidi; mso-bidi-language: FA;">Methods:</span></strong><span style="font-size: 12.0pt; line-height: 150%; font-family: 'Times New Roman',serif; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-theme-font: major-bidi; mso-bidi-language: FA;"> Literature from 2011-2025 (PubMed, Scopus, Web of Science) was reviewed, prioritizing comparative studies, case series (n≥20), and biomarker data; a key 100-patient cohort provided head-to-head analysis.​</span><br><strong><span style="font-size: 12.0pt; line-height: 150%; font-family: 'Times New Roman',serif; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-theme-font: major-bidi; mso-bidi-language: FA;">Results:</span></strong><span style="font-size: 12.0pt; line-height: 150%; font-family: 'Times New Roman',serif; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-theme-font: major-bidi; mso-bidi-language: FA;"> Retroperitoneoscopic decortication shows superior outcomes versus ureteroscopy: shorter operative time (78±18 vs 112±24 min), less blood loss (25±15 vs 55±30 mL), faster recovery (hospital stay 2.8±0.9 vs 5.1±1.4 days), lower complications (8% vs 18%), and greater IL-6/TNF-α decline; recurrence rates similar (8-10%).​</span><br><strong><span style="font-size: 12.0pt; font-family: 'Times New Roman',serif; mso-ascii-theme-font: major-bidi; mso-fareast-font-family: DengXian; mso-fareast-theme-font: minor-fareast; mso-hansi-theme-font: major-bidi; mso-bidi-theme-font: major-bidi; mso-font-kerning: 1.0pt; mso-ansi-language: EN-US; mso-fareast-language: ZH-CN; mso-bidi-language: FA;">Conclusion:</span></strong><span style="font-size: 12.0pt; font-family: 'Times New Roman',serif; mso-ascii-theme-font: major-bidi; mso-fareast-font-family: DengXian; mso-fareast-theme-font: minor-fareast; mso-hansi-theme-font: major-bidi; mso-bidi-theme-font: major-bidi; mso-font-kerning: 1.0pt; mso-ansi-language: EN-US; mso-fareast-language: ZH-CN; mso-bidi-language: FA;"> Retroperitoneoscopic decortication is optimal for symptomatic peripelvic cysts, balancing efficacy, safety, and biomarker recovery over ureteroscopy</span> https://www.threports.com/article_236665_b846e4b0fcc9ea2b510a18554fe444da.pdf