Mazandaran Association of Emergency Medicine Translational Health Reports 3092-6750 2 1 2025 12 20 A Comparative Analysis of Primary Radiotherapy versus Transoral Surgery for Early-Stage Laryngeal Squamous Cell Carcinoma: Oncologic and Functional Results 236666 10.22034/thr.2025.236666 EN Feruza Ruzimova Department of Pedagogy and Psychology , Urgench State University, Urgench, Uzbekistan Sevara Sadullayeva Department of Psychological Sciences , Mamun University, Khiva, Uzbekistan Madrimov Javoxir Islombek O'g'li Department of Medicine, Urgench Mamun University, Urgench, Uzbekistan Niginabonu Khajiqurbonova Department of Clinical Subjects, Tashkent State Medical University, Tashkent, Uzbekistan Fayzullayev Umidjon O'ktamovich Department of Psychology, Mamun University, Khiva, Uzbekistan Xudoynazarova Dilnura Department of Psychology, Mamun University, Khiva, Uzbekistan Uktamova Shoxida Department of Pedagogy and Psychology, Urgench State University, Urgench, Uzbekistan Seyed Mohammad Hossein Mousavi Assistant Professor of General Surgery, Surgical Oncology Fellowship Shahid Sadoughi University of Medical Sciences, Yazd, Iran 0000-0002-6164-3224 Journal Article Backgrounds: Early-stage laryngeal squamous cell carcinoma (LSCC), which includes stage I and II disease, has a high cure rate. The main treatment approaches are definitive radiotherapy (RT) and transoral surgery (TOS), which includes transoral laser microsurgery (TLM) and transoral robotic surgery (TORS). Selecting the optimal treatment involves balancing oncologic effectiveness with functional results and quality of life. Objective: To review and compare current evidence on overall survival (OS), disease-specific survival (DSS), laryngeal preservation (LP), and functional outcomes in early-stage LSCC treated with primary RT or TOS. Methods: A narrative literature review was performed, identifying relevant studies from PubMed and Scopus. The focus was on peer-reviewed articles from the last two decades, including retrospective cohort studies, prospective trials, systematic reviews, and meta-analyses that directly compared RT and TOS. Results: Recent large-scale analyses and meta-analyses show similar overall and disease-specific survival rates for T1 and T2 tumors treated with modern TOS or RT. The main differences are seen in patterns of oncologic control. TOS is linked to lower local recurrence but a higher incidence of second primary tumors, whereas RT shows higher local recurrence but a lower need for salvage laryngectomy, resulting in comparable long-term laryngeal preservation rates. Functionally, TOS offers advantages in treatment duration, voice outcomes for select T1a lesions, and cost-effectiveness, but may lead to poorer swallowing outcomes for larger resections. RT may provide better voice quality for more extensive T1 and T2 lesions but carries risks of long-term dry mouth and tissue scarring. Conclusion: Both RT and TOS are effective treatments for early-stage LSCC, with similar long-term survival outcomes. Treatment selection should be individualized, based on tumor characteristics, patient health, institutional experience, and patient preferences regarding functional trade-offs and treatment burden.

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