Mazandaran Association of Emergency Medicine Translational Health Reports 3092-6750 2 1 2025 12 20 The Role of Early Intravenous Immunoglobulin and Nursing Process Optimization in Modulating Inflammation and Improving Outcomes in Pediatric Severe Adenovirus Pneumonia: A Comprehensive Review 236668 10.22034/thr.2025.236668 EN Salayeva Navbahor Department of Pedagogy and Psychology, Urgench State University, Urgench, Uzbekistan Docent. Sevara Sadullayeva Department of Psychological Sciences, Mamun University, Khiva, Uzbekistan Ollaberganov Zayniddin Umarbekovich Department of Medicine, Urgench Mamun University, Urgench, Uzbekistan Niginabonu Khajiqurbonova Department of Clinical Subjects, Tashkent State Medical University, Tashkent, Uzbekistan Sultanov Muhammad Department of Psychology, Mamun University, Khiva, Uzbekistan Saginova Aygerim Sisenbayevna Department of Medicine, Urgench Mamun University, Urgench, Uzbekistan Journal Article Background: Severe adenovirus pneumonia (SAP) in children is a critical illness characterized by a dysregulated hyperinflammatory response. The adjunctive role of early intravenous immunoglobulin (IVIG) and optimized nursing care in modulating this inflammation remains a key area of clinical investigation. Objective: This review evaluated current evidence on the efficacy of early IVIG administration and nursing process optimization (NPO) in improving clinical and biochemical outcomes for pediatric SAP. Methods: A comprehensive analysis of clinical studies, including a pivotal randomized controlled trial was conducted. The review focuses on IVIG's immunomodulatory mechanisms and the impact of structured nursing interventions on care delivery. Results: Early IVIG administration is associated with significant reductions in key inflammatory markers (CRP, PCT, IL-8) and leads to superior clinical outcomes, including shorter hospital stays, fever duration, and mechanical ventilation requirements, alongside lower complication rates. Concurrently, implementing NPO protocols dramatically reduces infusion-related adverse events. <span style="font-size: 12.0pt; line-height: 115%; font-family: 'Segoe UI',sans-serif; mso-fareast-font-family: 'Times New Roman'; color: #0f1115; mso-font-kerning: 0pt; mso-ligatures: none; mso-ansi-language: EN-US; mso-fareast-language: EN-US; mso-bidi-language: AR-SA;">Conclusion:<span style="font-size: 12.0pt; line-height: 115%; font-family: 'Segoe UI',sans-serif; mso-fareast-font-family: 'Times New Roman'; color: #0f1115; mso-font-kerning: 0pt; mso-ligatures: none; mso-ansi-language: EN-US; mso-fareast-language: EN-US; mso-bidi-language: AR-SA;"> The synergistic application of early IVIG and NPO presents a promising, holistic strategy for managing pediatric SAP by effectively modulating inflammation and enhancing the safety of care delivery. This combined approach warrants broader clinical adoption and further long-term study

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