Document Type : Review Article
Authors
1
Trauma and Surgery Research Center, Aja University of Medical Sciences, Tehran, Iran
2
Toxicology Research Center, Aja University of Medical Sciences, Tehran, Iran
3
Orthopedic Surgeon, Orthopedic Research Center, Mazandaran University of Medical Sciences, Sari, Iran
4
Associate Professor of Anesthesiology and Pain, Pain Specialist, Department of Anesthesiology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
5
Anesthesiologist, Mazandaran University of Medical Sciences, Sari, Iran
6
Fellowship Pain Medicine, Department of Anesthesiology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
7
Student Research Center, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
Abstract
Introduction: Osteoporosis is a widespread bone disease characterized by low bone mineral density (BMD), structural bone deterioration, and an increased risk of fractures. It primarily affects postmenopausal women and the elderly, representing a significant global health burden. The management of osteoporosis involves pharmacological treatments aimed at preventing fractures, alleviating symptoms, and improving overall quality of life.
Methods: This review analyzes the pharmacology of current osteoporosis treatments, including bisphosphonates, selective estrogen receptor modulators (SERMs), monoclonal antibodies, and newer agents such as sclerostin inhibitors. It also examines pain management strategies, particularly those targeting fracture-related pain, and explores the intersection between bone therapies and analgesia.
Results: The current pharmacological treatments for osteoporosis have shown significant efficacy in reducing fracture risk. However, managing pain in osteoporosis, particularly post-fracture pain, remains a complex challenge. This review highlights the need for a multidimensional approach that integrates both bone-targeted therapies and effective pain management strategies.
Conclusion: While osteoporosis therapies have greatly reduced fracture risk, pain management in osteoporosis patients remains an area requiring further research. This review synthesizes current literature on osteoporosis treatments and pain management, offering insights into best practices and identifying future research directions to improve patient outcomes.
Keywords
