Translational Health Reports

The Role of Early Intravenous Immunoglobulin and Nursing Process Optimization in Modulating Inflammation and Improving Outcomes in Pediatric Severe Adenovirus Pneumonia: A Comprehensive Review

Document Type : Review Article

Authors

Salayeva Navbahor 1
Docent. Sevara Sadullayeva 2
Ollaberganov Zayniddin Umarbekovich 3
Niginabonu Khajiqurbonova 4
Sultanov Muhammad 5
Saginova Aygerim Sisenbayevna 3

1 Department of Pedagogy and Psychology, Urgench State University, Urgench, Uzbekistan

2 Department of Psychological Sciences, Mamun University, Khiva, Uzbekistan

3 Department of Medicine, Urgench Mamun University, Urgench, Uzbekistan

4 Department of Clinical Subjects, Tashkent State Medical University, Tashkent, Uzbekistan

5 Department of Psychology, Mamun University, Khiva, Uzbekistan

https://doi.org/10.22034/thr.2025.236668
Abstract
Background: Severe adenovirus pneumonia (SAP) in children is a critical illness characterized by a dysregulated hyperinflammatory response. The adjunctive role of early intravenous immunoglobulin (IVIG) and optimized nursing care in modulating this inflammation remains a key area of clinical investigation.
Objective: This review evaluated current evidence on the efficacy of early IVIG administration and nursing process optimization (NPO) in improving clinical and biochemical outcomes for pediatric SAP.
Methods: A comprehensive analysis of clinical studies, including a pivotal randomized controlled trial was conducted. The review focuses on IVIG's immunomodulatory mechanisms and the impact of structured nursing interventions on care delivery.
Results: Early IVIG administration is associated with significant reductions in key inflammatory markers (CRP, PCT, IL-8) and leads to superior clinical outcomes, including shorter hospital stays, fever duration, and mechanical ventilation requirements, alongside lower complication rates. Concurrently, implementing NPO protocols dramatically reduces infusion-related adverse events.
Conclusion: The synergistic application of early IVIG and NPO presents a promising, holistic strategy for managing pediatric SAP by effectively modulating inflammation and enhancing the safety of care delivery. This combined approach warrants broader clinical adoption and further long-term study

Keywords

Immunoglobulin
Pediatric
Adenovirus
Pneumonia

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